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Dario R Alessi Selected Research

Protein Kinases (Protein Kinase)

1/2021Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites.
1/2018Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks.
1/2018Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase.
6/2013Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.
1/2013Kinase drug discovery--what's next in the field?
5/2011Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.
1/2011Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.
12/2009Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
10/2009Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
12/2008Small-molecule inhibitors of PDK1.
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Dario R Alessi Research Topics

Disease

48Parkinson Disease (Parkinson's Disease)
12/2021 - 07/2007
36Neoplasms (Cancer)
10/2019 - 03/2002
19Hypertension (High Blood Pressure)
01/2022 - 02/2004
8Pseudohypoaldosteronism
01/2022 - 02/2004
6Insulin Resistance
10/2012 - 09/2007
5Breast Neoplasms (Breast Cancer)
10/2019 - 01/2009
4Carcinogenesis
11/2014 - 10/2005
3Hyperkalemia
01/2021 - 03/2009
3Type 2 Diabetes Mellitus (MODY)
09/2009 - 08/2004
2COVID-19
01/2021 - 12/2020
2Colorectal Neoplasms (Colorectal Cancer)
06/2012 - 03/2005
1Dementia (Dementias)
01/2021
1Huntington Disease (Huntington's Disease)
01/2018
1Inflammation (Inflammations)
01/2018
1Infections
01/2018
1Gitelman Syndrome
08/2015
1Pancreatic Neoplasms (Pancreatic Cancer)
11/2014
1Autistic Disorder (Autism)
07/2014
1Schizophrenia (Dementia Praecox)
07/2014
1Essential Hypertension
07/2014
1Neuralgia (Stump Neuralgia)
07/2014
1Epilepsy (Aura)
07/2014
1Chronic Disease (Chronic Diseases)
04/2013
1Adenocarcinoma
03/2013
1Metaplasia
03/2013
1Autoimmune Diseases (Autoimmune Disease)
01/2013
1Fibrosis (Cirrhosis)
01/2013
1Ureteral Obstruction
01/2013
1Hyperinsulinism (Hyperinsulinemia)
10/2012
1Glomerulonephritis
10/2012
1Leprosy (Hansen's Disease)
10/2012
1Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2012
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
10/2012
1Liddle Syndrome
05/2012

Drug/Important Bio-Agent (IBA)

68Phosphotransferases (Kinase)IBA
12/2021 - 12/2002
21Leucine (L-Leucine)FDA Link
01/2021 - 04/2011
18Protein Kinases (Protein Kinase)IBA
01/2021 - 03/2002
9Proteins (Proteins, Gene)FDA Link
01/2021 - 03/2005
7Lysine (L-Lysine)FDA Link
01/2018 - 02/2004
7SaltsIBA
08/2015 - 10/2008
7AMP-Activated Protein KinasesIBA
04/2013 - 01/2003
6Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
11/2021 - 12/2002
6Pharmaceutical PreparationsIBA
12/2020 - 10/2008
6rab GTP-Binding ProteinsIBA
01/2020 - 01/2016
6Protein Isoforms (Isoforms)IBA
10/2019 - 05/2008
6Phosphatidylinositols (Phosphatidylinositol)IBA
10/2019 - 12/2002
5Leucine-Rich Repeat ProteinsIBA
01/2018 - 10/2009
4Leucine-Rich Repeat Serine-Threonine Protein Kinase-2IBA
11/2020 - 01/2016
4Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2018 - 03/2005
3DNA (Deoxyribonucleic Acid)IBA
01/2021 - 12/2002
3Mechanistic Target of Rapamycin Complex 1IBA
10/2019 - 06/2008
3Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2019 - 04/2013
3Angiotensin IIIBA
01/2018 - 03/2009
3EnzymesIBA
05/2014 - 12/2002
3TOR Serine-Threonine KinasesIBA
05/2011 - 06/2008
3Insulin (Novolin)FDA Link
01/2011 - 02/2005
3Metformin (Glucophage)FDA LinkGeneric
09/2009 - 08/2004
3Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
01/2009 - 02/2004
2Proline (L-Proline)FDA Link
01/2022 - 10/2012
2capivasertibIBA
01/2019 - 06/2013
2Alanine (L-Alanine)FDA Link
01/2018 - 10/2012
23-Phosphoinositide-Dependent Protein KinasesIBA
11/2014 - 03/2013
2GlucocorticoidsIBA
01/2013 - 01/2011
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
10/2012 - 03/2005
2Sirolimus (Rapamycin)FDA Link
06/2012 - 10/2005
2TensinsIBA
11/2011 - 06/2008
2Glucose (Dextrose)FDA LinkGeneric
03/2011 - 02/2005
2P-2 (P 2)IBA
03/2011 - 10/2005
2Ribosomal Protein S6 Kinases (S6 Kinase)IBA
01/2011 - 01/2009
2Serine (L-Serine)FDA Link
09/2010 - 10/2009
2Adenosine Monophosphate (AMP)IBA
12/2009 - 05/2006
2Blood Glucose (Blood Sugar)IBA
09/2009 - 06/2008
1LDL Receptors (LDL Receptor)IBA
01/2021
1Cullin Proteins (Cullins)IBA
01/2021
1alpha-SynucleinIBA
01/2020
1serum-glucocorticoid regulated kinaseIBA
10/2019
14- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
10/2019
12- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA
01/2019
1Epithelial Sodium ChannelsIBA
01/2018
1AldosteroneIBA
01/2018
1AntibodiesIBA
01/2018
1RNA (Ribonucleic Acid)IBA
01/2017
1Mitochondrial Proteins (Mitochondrial Protein)IBA
08/2015
1Recombinases (Recombinase)IBA
11/2014
1Analgesics (Analgesic Drugs)IBA
07/2014
1PTEN-induced putative kinaseIBA
05/2014
1UbiquitinIBA
05/2014
1Indicators and Reagents (Reagents)IBA
03/2014
1MK 2206IBA
06/2013
1Glycogen Synthase Kinase 3IBA
01/2013
1Glycogen Synthase KinasesIBA
01/2013
1GSK 2334470IBA
12/2012
1MTOR InhibitorsIBA
12/2012
1Antinuclear AntibodiesIBA
10/2012
1Immunoglobulin G (IgG)IBA
10/2012
1tetra-4-amidinophenoxypropane (TAPP)IBA
10/2012
1SodiumIBA
10/2012
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
06/2012
1I-kappa B KinaseIBA
01/2012

Therapy/Procedure

7Therapeutics
10/2019 - 07/2008